Analysis on Drug Combination Rule in Mutual Restraint Based on Apriori and Clustering Algorithm / 中国中医药信息杂志

ABSTRACT

Objective To investigate the drug combination of mutual restraint which is one of the application of seven different combination in drug in traditional Chinese medicine. Methods With the methods of association rules and complex system entropy clustering, we analyzed the drug combinations of mutual restraint that were collected from Compendium of Material Medica, to obtain the frequence of the single drug and drug combination of mutual restraint and the association rules between them. Results The single drugs with higher frequency are Rhizoma Coptidis, Fructus Crotonis, Rhei Radix Et Rhizoma, Azurite, Rhizoma Acori Tatarinowii, etc. The drug combinations with higher frequency are Azurite and Artemisia capillaries, Fructus Crotonis and Rhizoma Coptidis, Fructus Crotonis and Soybean etc. The associative drug combinations which confidence is 1 include “Indigo juice → Fructus Crotonis”,“Indigo juice → Rhizoma Coptidis”, etc. Conclusion The drug combinations of mutual restraint mainly include mineral drugs, antipyretics, purgatives, and toxic drugs.