Effect of neoadjuvant chemotherapy on locally advanced non-small cell lung cancer tumor markers and lymphocyte subsets / 重庆医学

ABSTRACT

Objective To observe and analyze the effect of neoadjuvant chemotherapy on locally advanced non-small cell lung cancer tumor markers and lymphocyte subsets of different pathological type .Methods A total number of 40 NSCLC patients which received neoadjuvant chemotherapy and 20 normal people were selected in our study .To compare the differences of CEA ,CA-125 , CYFRA21-1 and lymphocyte subset in NSCLC pantients with adenocarcinoma or squamous cell carcinoma and the the differences of CEA ,CA-125 ,CYFRA21-1 and lymphocyte subset in patients with different clinical effect .Results (1) The CEA ,CA-125 ,CY-FRA21-1 in pantients with adenocarcinoma or squamous cell carcinoma were both higher than normal people .The CEA level in pa-tients with adenocarcinoma was higher than squamous cell carcinoma ,while the CA-125 and CYFRA21-1 in squamous cell carcino-ma were higher than adenocarcinoma .The CD3+ ,CD4+ ,CD8+ ,CD4+ /CD8+ in pantients with adenocarcinoma or squamous cell carcinoma both had obvious differences with normal people .But there were no obvious differences between patients with adenocarci-noma and squamous cell carcinoma .(2)There were 18 cases of CR+ PR while 22 cases of SD+ PD .The CA-125 and CYFRA21-1 were decreased in patients of squamous cell carcinoma with clinical effective while the CEA and CYFRA 21-1 were decreased in ade-nocarcinoma with clinical effective .The CD3+ ,CD4+ ,CD4+ /CD8+ increased and CD8+ decreased in patients of squamous cell car-cinoma or adenocarcinoma with clinical effective .Conclusion The tumor marker and lymphocyte subsets values had obvious differ-ences in adenocarcinoma and squamous cell carcinoma .Both tumor marker and lymphocyte subsets were useful in diagnosis .