Expressions of Caveolin-1 and PCNA in esophageal squamous cell carcinoma and its biological significance in 150 cases / 重庆医学
Chongqing Medicine
;
(36): 3889-3890,3893, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-598660
ABSTRACT
Objective To explore the expression levels and significance of Caveolin-1 and proliferating cell nuclear antigen (PC-NA) in esophageal squamous cell carcinoma .Methods Immunohistochemical SP method was used to detect the expression levels of caveolin-1 and PCNA in 150 cases of esophageal squamous cell carcinoma and 35 cases of normal esophageal squamous cell . Results The expressions of Caveolin-1 in esophageal carcinoma was significantly higher than in normal esophageal mucosa (P<0 .05) ,caveolin-1 was related to lymph node metastasis ;The expressions of PCNA in esophageal carcinoma was significantly higher than in normal esophageal mucosa(P<0 .05) ,PCNA was related to age ,lymph node metastasis and tumor size .The expression of Caveolin-1 was positively correlated with PCNA (r=0 .266 ,P<0 .05) .Conclusion Caveolin-1 and PCNA overexpression might be related to the occurrence ,development and metastasis of esophageal squamous cell carcinomas .
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chongqing Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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