Compatible Stability of Sodium Nitroprusside for Injection in Two Infusions / 中国药师

ABSTRACT

Objective:To evaluate the compatible stability of sodium nitroprusside for injection ( SNP) in two kinds of solutions (5% glucose and sodium chloride injections) . Methods:A, B, C and D solution of SNP was respectively prepared according to the concentration of clinical use. The stability of SNP solution was studied in different environment with different storing time, and the as-sessment indices included the appearance, insoluble particles, pH value, ultraviolet-visible absorption spectrum and SNP content. Re-sultsThe SNP solutions in 5% glucose and sodium chloride injections were stable in 26 hours in photophobic condition at 20℃ and 35℃. Under an incandescent lamp with or without lightproof, the solutions were very unstable. Conclusion:Both sodium chloride and 5% glucose injections can be used as the solvent for SNP with 26h stability. SNP injections prepared and used in clinics should be pre-served away from light to ensure the safety and effectiveness.