Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins
Biomolecules & Therapeutics
;
: 284-289, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-59931
ABSTRACT
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas
/
Glicemia
/
Anafilaxia Cutânea Passiva
/
Morte Celular
/
Técnicas de Cultura de Células
/
Zea mays
/
Células Secretoras de Insulina
/
Polifenóis
/
Insulina
/
Antocianinas
Limite:
Animais
Idioma:
Inglês
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2013
Tipo de documento:
Artigo
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