Evaluation methods in vitro and in vivo for dry powder inhalers:research advances / 国际药学研究杂志

ABSTRACT

Drug delivery to lungs is becoming an important means of administration of some drugs for lung disease and some protein drugs with systemic effects. This article introduces the inhalation devices and particle characteristics,the two main features of dry powder inhalers (DPI), then reviews the advances on evaluation methods in vitro and in vivo for DPI, such as next generation pharmaceutical impactor (NGI), the imitation between particles and cells using electrodynamic levitation, hydraulic lung and dry powder endotracheal insufflator device, providing references for research and development of DPI evaluation methods.