Clinical significance of combined determination of liver fibrosis indexes from liver disease patients′serum / 重庆医学

ABSTRACT

Objective To explore the application value of combined detection of serum hyaluronic acid(HA) ,procollagen type Ⅲ(PCⅢ) ,laminin(LN) and collagen type Ⅳ(CⅣ) .Methods Immunoradiometric analysis was conclucted to detet the index levels of serum HA ,PC Ⅲ ,LN and C Ⅳ in 81 patients with liver disease(24 cases in hepatitis group ,39 cases in liver cirrhosis group ,18 ca-ses in liver cancer group) and 40 healthy adult(control group) .Then compared the differences of 4 indicators among groups .Results Four index levels of serum liver fibrosis from liver disease patients were higher than those of control group(P< 0 .05 or P<0 .01) ,HA level of liver cirrhosis group and liver cancer group were significantly higher than that in hepatitis group (P<0 .05 ,P<0 .01)HA level of liver cancer group was higher than that of liver cirrhosis group(P<0 .05) ,liver cirrhosis was higher than hepati-tis group(P<0 .05) .Conclusion Combined determination of the serum HA ,PCⅢ ,LN and CⅣ has importantly clinical significance in early diagnosis and prognosis of hepatic fibrosis .