Value of combined detection of tumor type M2 pyruvate kinase,tissue polypeptide specific antigen and carcino-embryonic antigen in diagnosis of colorectal cancer / 国际检验医学杂志

ABSTRACT

Objective To explore the clinical value of the combined detection of tumor type M2 pyruvate kinase (tumor M2-PK),tissue polypeptide specific antigen (TPS)and carcino-embryonic antigen (CEA)in the diagnosis of colorectal cancer.Methods The serum level of TPS and CEA,and the level of tumor M2-PK in fecal were detected in 74 patients with colorectal cancer and 60 healthy volunteers in our hospital.The sensitivity,specificity and accuracy were performed the comparative analysis between the single detection and the combined detection.Results The serum levels of TPS,CEA and the level of tumor M2-PK in fecal in the colorectal cancer observation group were significantly higher than those in the healthy control group (P <0.05).There were signifi-cant differences in the sensitivity,specificity and accuracy of TPS,CEA and tumor M2-PK between and the combined detection (P <0.05).In the comparison among the single detection of 3 tumor markers and between the single marker detection with the combined detection,the sensitivity,specificity and accuracy of any single marker measurement was lower than that in the combined detection of 3 markers.Conclusion The combined detection of TPS,CEA and tumor M2-PK can improve the sensitivity,specificity and accuracy in diagnosing colorectal cancer.