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Research strategy of the case-control post-genome-wide association study / 天津医药
Tianjin Medical Journal ; (12): 810-812,813, 2015.
Artigo em Chinês | WPRIM | ID: wpr-600620
ABSTRACT
Since the first paper reported the finding of genetic variation contributing to human age-related macular de?generation by genome-wide association study (GWAS) in 2005, large number of human complex diseases associated genetic variants have been identified through GWAS method. However, the biological function of these genetic variants is not very clear. The present paper reviewed the methods of fine-mapping and the progress of the functional studies for these suscepti?bility variants. In the post GWAS Era, the study of genetic mechanisms can help us to understand the disease pathogenesis.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Chinês Revista: Tianjin Medical Journal Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Chinês Revista: Tianjin Medical Journal Ano de publicação: 2015 Tipo de documento: Artigo