Effect of Reduning injection on INR,PT and APTT levels in patients with Trimeresurus stejnegeri bite / 重庆医学

ABSTRACT

Objective To investigate the effect of Reduning injection(RI)on international normalized ratio(INR) ,prothrombin time(PT)and activated partial thromboplastin time(APTT)levels in patients with Trimeresurus stejnegeri(TS)bite .Methods Three hundred cases of patients with TS bite in our hospital from July 2010 to July 2013 were randomly divided into 2 groups .The control group received the routine treatment while the observation group treated with RI besides ,and then compared the growth of symptoms ,effect and changes of INR ,PT and APTT of 2 groups .Results The observation group′s swelling time [(127 .8 ± 56 .2) h] ,analgesic time [(5 .3 ± 2 .7)h] ,hospitalization time [(3 .8 ± 2 .7)d] was lower than those of the control group[ (150 .3 ± 83 .4) h ,(11 .5 ± 6 .1)h ,(5 .8 ± 4 .4)d] .The INR ,PT and APTT of 2 groups after treatment were both extended .However ,the extended degree of observation group was much lower .The observation group′s cure rate [90 .00% (135/150)] ,markedly effective rate [98 .00% (147/150)]were higher than those of the control group [67 .33% (101/150) ,84 .67% (127/150)] ,which showed statisti‐cally significant difference(P<0 .05) .Conclusion RI shows good effect on curing TS bite patients and could effectively shorten the time for symptom improvement and inhibit the prolonged coagulation index .