Immunoprotective mechanisms of estrogen on experimental autoimmune encephalomyelitis:research advances / 国际药学研究杂志

ABSTRACT

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease model mediated by specific allergenic CD4+T cell and accompanied by mononuclear cells invasion in central nervous system (CNS) and demyelination. Similar to the histopathology and immune characters of multiple sclerosis(MS), EAE has been used as a classical animal model for the study of MS. In recent years, as an immune regulator for the treatment of relapsing-remitting MS, study of estrogen has entered the pre-clinical phaseⅡtrials. Larger numbers of studies have verified that high concentration of estrogen could improve EAE. However, the specific mechanisms are still in controversy. For these considerations, this review summarizes the protective mechanisms of estrogen in EAE.