Detection of EWSR1 gene translocation in paraffin-embedded Ewing family tumor by fluores-cence in situ hybridization / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
;
(12): 302-305,306, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-600994
ABSTRACT
Purpose To evaluate the application of fluorescence in situ hybridization ( FISH) in detection of EWSR1 gene translocation in formalin-fixed paraffin-embedded tissue samples of Ewing family tumor ( EFT) . Methods Four cases of EFT were collected and their clinical pathological features were obsered. Interphase FISH was carried out in paraffin-embedded tissue of EFT cases, using a EWSR1 dual colar break-apart probe. Fifteen cases of other soft tissue tumor were selected as negative control. Results Translocation of EWSR1 was detected in four EFT cases, which may be a adjuvantly diagnositic value for the diagnosis of atypical cases. Conclu-sions FISH may serve as an adjunctive diagnostic tool in problematic cases of EFT, however, FISH results should be interpreted con-cerning clinical pathological features, morphological patterns and immunohistological results.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Chinese Journal of Clinical and Experimental Pathology
Ano de publicação:
2015
Tipo de documento:
Artigo
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