Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing
Immune Network
;
: 412-415, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-60131
ABSTRACT
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2K(b)-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Perileno
/
Quinonas
/
Células Dendríticas
/
Apresentação de Antígeno
/
Citosol
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2011
Tipo de documento:
Artigo
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