Comparison of Invariant NKT Cells with Conventional T Cells by Using Gene Set Enrichment Analysis (GSEA)
Immune Network
;
: 406-411, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-60132
ABSTRACT
BACKGROUND:
Invariant Natural killer T (iNKT) cells, a distinct subset of CD1d-restricted T cells with invariant Valphabeta TCR, functionally bridge innate and adaptive immunity. While iNKT cells share features with conventional T cells in some functional aspects, they simultaneously produce large amount of Th1 and Th2 cytokines upon T-cell receptor (TCR) ligation. However, gene expression pattern in two types of cells has not been well characterized.METHODS:
we performed comparative microarray analyses of gene expression in murine iNKT cells and conventional CD4+CD25-gammadeltaTCR- T cells by using Gene Set Enrichment Analysis (GSEA) method.RESULTS:
Here, we describe profound differences in gene expression pattern between iNKT cells and conventional CD4+CD25-gammadeltaTCR- T cells.CONCLUSION:
Our results provide new insights into the functional competence of iNKT cells and a better understanding of their various roles during immune responses.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Expressão Gênica
/
Citocinas
/
Competência Mental
/
Células T Matadoras Naturais
/
Imunidade Adaptativa
/
Ligadura
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2011
Tipo de documento:
Artigo
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