MDSCs are upregulated in PSGL-1-deficient mice / 中国比较医学杂志
Chinese Journal of Comparative Medicine
;
(6): 42-44,45, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-601349
ABSTRACT
Objective PSGL-1 is specifically expressed in leucocytes.The aim of this study was to explore the changes of myeloid-derived suppressor cells (MDSCs) in the spleen and bone marrow in PSGL-1-deficient mice.Methods PSGL-1 -/-mice were used in the experiment.After identification of the offsprings, flow cytometry was used to test the expression of CD11b and Gr-1 in C57 and PSGL-1 -/-mice.Results Compared with the C57 mice, the expression of MDSCs was up-regulated in the PSGL-1-deficient mice ( P <0.001).Conclusion The expression of MDSCs is upregulated in PSGl-1-deficient mice.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Comparative Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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