The influence of different method of mediastinal lymph node excision on perioperative immune function of lung cancer patients / 肿瘤研究与临床

ABSTRACT

Objective To explore the influence of different method of mediastinal lymph node excision on the immune function of non-small cell lung cancer patients.Metbods Clinical data was collected continuously from 415 cases of inhospital patients with non-small cell lung cancer from March 2009 to March 2012,who were divided into system lymph node dissection group (SLND,216 cases) and lymph node sampling group (LNS,199 cases).The total lymphocytes,NK cells,CD4+ T cells and CD8+ T cells in blood samples taken preoperatively and at 3rd and 7th day postoperation were analyzed.Results Total lymphocytes,NK cells and CD8+ T cells were reduced significantly in the SLND group compared with those in LNS group at 3rd day and 7th day postoperation (3rd dayLC (0.95±0.57) × 109/L vs (1.10±0.65) × 109/L,CD8+ T cells (19.53± 6.48) ％ vs (20.93±6.70) ％,NK (17.36±6.06) ％ vs (18.57±5.97) ％,P ＜ 0.05; 7th dayLC (0.86±0.53) × 109/L vs (1.00±0.60) × 109/L,CD8+ T cells (17.27±5.64) ％ vs (18.40±5.26) ％,NK (13.11±4.84) ％ vs (14.20± 5.30) ％; P ＜ 0.05).CD4+ T cells in the SLND group were reduced significantly at 3rd day postoperation compared with LNS group ((29.59±6.53) ％ vs (31.19±6.32) ％,P ＜ 0.05).Conclusion LNS can reduce immunosuppression compared with SLND for postoperative patients.