The effects of HBeAg and HBV DNA in chronic hepatitis B during late trimester of pregnancy on the postpartum hepatic inflammation / 国际检验医学杂志

ABSTRACT

Objective To explore the effects of hepatitis B e-antigen(HBeAg)and hepatitis B virus(HBV)DNA load during late trimester of pregnancy on postpartum chromic hepatitis B with acute exacerbation in female patients with chronic hepatitis B (CHB).Methods 1 14 cases of pregnant women with CHB treated in this hospital from March 2010 to June 2014 were selected and divided into the hepatitis B with acute exacerbation group and hepatitis B without acute exacerbation group.The general demograph-ic data and clinical information of these patients were collected,and serum HBV DNA loads and levels of alanine aminotransferase (ALT)were detected during late trimester of pregnancy(between the 28th to 36th weeks of pregnancy)and postpartum(6 to 12 weeks postpartum).The effects of HBeAg and HBV DNA loads on postpartum chromic hepatitis B with acute exacerbation were analysed.Results 24.6% of female patients was diagnosed with postpartum chromic hepatitis B with acute exacerbation.The inci-dence rate of postpartum chromic hepatitis B with acute exacerbation in female patients with positive HBeAg during late trimester of pregnancy increased,compared those with negative HBeAg,had statistically significant differences(P 0.05).The hepatic flare was correlated with the HBeAg status,but was not related with HBV DNA load.Conclusion Post-partum chromic hepatitis B with acute exacerbation might not be correlated with HBV DNA loads,but correlated with HBeAg, which indicates that positive HBeAg during late trimester of pregnancy could be a risk factor for postpartum chromic hepatitis B with acute exacerbation.