Preparation and in vitro Drug Release of Betahistine Dihydrochloride Sustained-release Matrix Tablets / 中国药师
China Pharmacist
;
(12): 1665-1668,1669, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-602080
ABSTRACT
Objective:
To prepare betahistine dihydrochloride sustained-release matrix tablets.Methods:
The tablets were pre-pared with water soluble HPMC matrix, and the release behaviors were investigated by single factor study. The formula and preparation procedures were optimized by orthogonal design.Results:
The optimal technology was as followsusing 60% HPMC K15M as the ma-trix material, calcium hydrogen phosphate as the filler, 10% PVP in 90% alcohol as the bonding agent;wet granulation compression technique was used to prepare the tablets with the tablet weight of 500mg. The in vitro drug release fits a Higuchi equation and the drug can be sustained-released within 12 h.Conclusion:
The preparation technology is simple and the tablets have sustainol release behav-ior.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2014
Tipo de documento:
Artigo
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