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Preparation and in vitro Drug Release of Betahistine Dihydrochloride Sustained-release Matrix Tablets / 中国药师
China Pharmacist ; (12): 1665-1668,1669, 2014.
Artigo em Chinês | WPRIM | ID: wpr-602080
ABSTRACT

Objective:

To prepare betahistine dihydrochloride sustained-release matrix tablets.

Methods:

The tablets were pre-pared with water soluble HPMC matrix, and the release behaviors were investigated by single factor study. The formula and preparation procedures were optimized by orthogonal design.

Results:

The optimal technology was as followsusing 60% HPMC K15M as the ma-trix material, calcium hydrogen phosphate as the filler, 10% PVP in 90% alcohol as the bonding agent;wet granulation compression technique was used to prepare the tablets with the tablet weight of 500mg. The in vitro drug release fits a Higuchi equation and the drug can be sustained-released within 12 h.

Conclusion:

The preparation technology is simple and the tablets have sustainol release behav-ior.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacist Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacist Ano de publicação: 2014 Tipo de documento: Artigo