Expression of CCL17 in Serum of Patients with Rheumatoid Arthritis and Its Clinical Significance / 中国医科大学学报

ABSTRACT

Objective To investigate the expression levels of serum CCL17 in patients with rheumatoid arthritis(RA),so as to explore its clinical sig?nificance. Methods The expression of serum CCL17 was measured by ELISA in 40 RA patients and 20 normal individuals. The correlation of se?rum levels of CCL17 with clinical active index was analyzed. Results The serum level of CCL17 in RA patients was significantly higher than those in normal controls(P<0.05). Serum CCL17 level in patient with advanced disease(DAS28≥5.1)was higher than those in medium disease activity group(3.2≤DAS28<5.1)(P<0.05). The serum level of CCL17 in RA was obviously correlated with CRP,anti?CCP,the count of PLT(P<0.05). Conclusion High level of CCL17 expression was found in serum of RA patients. Our results also proved that serum level of CCL17 has certain cor?relation with disease activity index in RA patients,which indicates CCL17 may be involved in the process of the pathogenesis and progression of RA.