Omeprazole and Cimetidine for Stress Ulcer Bleeding Prophylaxis:A Meta-analysis / 中国药师
China Pharmacist
;
(12): 1925-1927,1977, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-602740
ABSTRACT
Objective:
To evaluate the efficacy of omeprazole and cimetidine in the prophylaxis of stress ulcer bleeding to provide evidence for clinical therapy in China.Methods:
The randomized controlled trials were searched in PubMed, Medline, CNKI, Wan-fang and Vip database with the key words of omeprazole, cimetidine and stress ulcer. Two evaluators assessed the quality and reviewed the data independently. RevMan 5. 2 software was used for Meta-analysis.Results:
Seventeen randomized controlled trials were includ-ed involving 892 patients for omeprazole group and 888 patients for cimetidine group. The results of Meta-analysis showed that the difference between the two groups after the treatment was statistically significant by comparing the incidence of stress ulcer bleeding (OR=0. 23,95% CI0. 17-0. 32;P<0. 000 01). The incidence of stress ulcer bleeding of omeprazole group was significantly lower than that of cimetidine group.Conclusion:
Existing literature analysis shows that omeprazole is more effective than cimetidine in the stress ulcer bleeding prophylaxis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
/
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2015
Tipo de documento:
Artigo
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