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Effects of Kunmu decoction on proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis / 实用医学杂志
The Journal of Practical Medicine ; (24): 2793-2795,2796, 2015.
Article em Zh | WPRIM | ID: wpr-602820
Biblioteca responsável: WPRO
ABSTRACT
Objective To investigate the effects of alcohol extract of Kunmu decoction on proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Methods Synovial tissues were obtained from patients with active RA received joint replacement or arthroscopy. The surface antigen and the amount of apoptotic cells were determined by flow cytometry. The inhibitive effect was detected by MTT assay. Results The CD90+surface antigen of synoviocytes was (94.78 ± 0.98)%. The inhibitive effect on the proliferation in all treatment groups were in a time-and dose-dependent manner. The apoptosis rate was increased in a dose-dependent manner among all dosage alcohol extract groups. Conclusion Kunmu decoction might inhibit proliferation and induce apoptosis of RA-FLS.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: The Journal of Practical Medicine Ano de publicação: 2015 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: The Journal of Practical Medicine Ano de publicação: 2015 Tipo de documento: Article