Effect of behavioral therapy combined with pramipexole on the degree of depression and non-motor symptoms in early-onset Parkinson’s disease and depression / 中国生化药物杂志

ABSTRACT

Objective To discuss the clinical effect of behavioral therapy combined with pramipexole in patients’ degree of depression and non-motor symptoms in early-onset Parkinson’s disease and depression.Methods A total of 74 cases of patients with early-onset Parkinson’s disease and depression were equally divided into observation group and control group, 37 cases in each groups.Patients in control group were given pramipexole, while patients in observation group were given pramipexole and behavioral therapy.The hamilton depression ( HAMD) scale, Zung self-rating depression scale and unified Parkinson’s disease rating scale ( UPDRS ) were used to evaluate and measure the change of degree of depression and non-motor symptoms.Results Before treatment, the HAMD score, Zung score, UPDRS II score and UPDRS III score between two groups had no statistical difference; after treatment, the HAMD score, Zung score, UPDRS II score and UPDRS III score in two groups were significantly decreased (P<0.05). The HAMD score, and Zung score between two groups had no statistical difference at the end of 4th weekends, and compared with control group, those scores in observation group were much better at the end of 8th and 12th weekend (P<0.05).The UPDRS II and UPDRS III between two group had no statistical difference at the end of 4-8th week, while those scores in observation group were better than those in control group at the end of 12th week(P<0.05).Conclusion Behavioral therapy combined with pramipexole has a great effect on the improvement of patients’ degree of depression and non-motor symptoms, which has a positive promotion on patients’ life quality.