Systematical review of drug resistance in Chinese HIV/AIDS patients after antiretroviral therapy / 中国感染控制杂志

ABSTRACT

Objective To understand drug resistance in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS)after antiretroviral therapy(ART).Methods Articles about drug resistance in HIV/AIDS patients after ART were retrieved from Wangfang data,China National Knowledge Infrastructure(CNKI),and PubMed. Meta analysis were performed.Results 15 articles (1 English and 14 Chinese) were extracted,quality score of 3,4,and 8 articles was 6,7,and 8 respectively. Heterogeneity of the included stud-ies showed the difference was significant (Q= 45.98,P<0.001),there was heterogeneity,random-effects models was conducted for Meta analysis,which revealed that the overall drug resistance rate in HIV/AIDS patients in China was 4% (4% -5% );Begg's test showed that P= 0.012,there was publication bias. After articles were excluded through sensitivity analysis,the combined effect was still 4% (4% -5% ).Conclusion The overall drug resistance rate in Chinese HIV/AIDS patients after ART is not high.