Clinicopathological analysis of supratentorial parenchymal ependymomas / 中国基层医药

ABSTRACT

Objective To study the clinicopathological characteristics and the immunohistochemistry of supratentorial parenchymal ependymoma.Methods The clinical and pathological data of 12 patients with supratento-rial parenchymal ependymoma were analyzed,and the tissue slices were immunohistochemically stained.Results The average age of the patients was 29 years old.Most of the lesions occurred in the frontal and parietal lobes,with increased intracranial pressure as the main clinical symptom,including headache,dizziness,nausea and vomiting.The histology showed that the structure of supratentorial parenchymal ependymoma was consistent with that of infratentorial ependymoma.The tumor cells were oval or spindle shaped,diffuse or patchy distribution,small volume,large nuclear staining deep,and were arranged in Flexner-Winterseiner or Homer-Wright.The immunohistochemistry showed that GFAP,vimentin and S-100 were mostly positive,EMA was partly positive and CD56 and NSE were rarely positive. Conclusion Supratentorial parenchymal ependymoma can occur in any part of the supratentorium,mostly in the fron-tal and parietal lobes.It has a specific pathological morphology and immune phenotype,without any characteristic symptoms in clinical,which is easy to be misdiagnosed.Its diagnosis depends on the pathological examination and the prognosis is largely related to whether the surgical resection is complete or not.