The combination of CRP,myocardial enzymes measurement and blood gas analysis in neonatal pneumonia / 国际检验医学杂志

ABSTRACT

Objective To investigate the clinical significance of combined detection of C‐reactive protein(CRP) ,myocardial en‐zyme spectrum and blood gas analysis in neonatal pneumonia ,and provide the basis for its diagnosis and treatment .Methods 152 neonatal pneumonia patients treated in the hospital from October 2013 to August 2014 were enrolled in the study as observation group .According to the condition and pathogenic examination results ,those patients were divided into severe pneumonia group(n=101) ,mild pneumonia group(n=51) and viral pneumonia group(n=76) ,bacterial pneumonia group(n=62)and other pneumonia group(n=14) ,simultaneously combined determination of CRP and myocardial enzymes and blood gas analysis were performed .The differences among the groups were analyzed and compared with 50 cases of healthy full‐term newborns(control group) .Results The myocardial enzyme spectrum and blood gas analysis of severe pneumonia and mild pneumonia group were abnormal in varying degrees .Except the detection results of aspartic acid amino transferase(AST) ,lactate dehydrogenase(LDH) ,alpha hydroxybutyrate dehydrogenase(HBDH) in mild group were not significantly different from that in control group(P>0 .05) ,the rest test itmes were all significantly different(P<0 .01) .C‐reactive protein (CRP) concentration increased significantly in bacterial pneumonia and was higher than other group(P<0 .01) .Blood gas analysis showed that in severe pneumonia group ,mixed acid poisoning was the major‐ity ,and the children with mild pneumonia group were mainly respiratory acidosis .Conclusion Neonatal pneumonia may cause myo‐cardial damage and pulmonary ventilation and gas exchange dysfunction ,and the detection of CRP and myocardial enzyme spectrum and blood gas analysis help early detection of myocardial injury and to know the injury degree ,master and correct acid‐base disturb‐ance ,hypoxemia ,improve the pulmonary ventilation function ,differential diagnosis of bacterial and non‐bacterial pneumonia .