Epalrestat,alprostadil combined with lipoic acid in the treatment of 44 elderly patients with diabetic peripheral neuropathy / 中国基层医药

ABSTRACT

Objective To investigate the effect of epalrestat,alprostadil combined with lipoic acid in the treatment of 44 elderly patients with diabetic peripheral neuropathy.Methods 44 elderly patients with diabetic peripheral neuropathy were selected,according to the random number table method they were divided into control group and observation group,22 cases in each group.The control group was treated with mecobalamin,the observation group was treated with epalrestat,alprostadil combined with lipoic acid.The clinical effects were compared between the two groups.Results The total effective rate of the observation group was 95.4%,which of the control group was 72.7%,the difference between the two groups was statistically significant(χ2 =7.94,P <0.05).In the observation group,the peroneal nerve and median nerve changes after treatment were significantly better than the control group,the differences were statistically significant(all P <0.05).Conclusion Epalrestat,alprostadil combined with lipoic acid in the treatment of elderly diabetic patients with peripheral neuropathy has obviously curative effect, and it can effectively improve the nerve conduction function.It is worthy of wide application in clinical treatment.