The expression of Fascin-1 in colorectal cancer and its clinical significance / 重庆医学

ABSTRACT

Objective To investigate the expression of Fascin‐1 in colorectal cancer (CRC) and its clinical significance .Meth‐ods Immunohistochemistry MaxVision method was adopted to detect the protein expression of Fascin‐1 in 87 CRC tissues and 28 para‐cancer tissues ,and analyzed the expressions of them and the relations to clinicopathologic characteristics .Kaplan‐Meier plots and Cox proportional hazards regression model were used to analyze the prognostic value of Fascin‐1 expression .Results The posi‐tive rates of Fascin‐1 expression in CRC tissues and para‐cancer tissues were 43 .7% (38/87) and 7 .1% (2/28) respectively ,with significant difference (P0 .05) .In the Kaplan‐Meier analysis ,patients with Fascin‐1 over‐expression had significantly shorter overall survival than those patients with negative Fascin‐1 expression (P=0 .009) .Multivari‐able analysis by Cox regression model further showed that Fascin‐1 over‐expression was a significantly independent predictor of poorer overall survival (HR=2 .087;95% CI1 .196-3 .642 ,P=0 .010) .Conclusion The expression of Fascin‐1 is high and its re‐lated to the long‐term survival time of patients with CRC .It is an independent prognostic factor for CRC .