Effect of Fluvastatin Adjuvant Therapy on Plasma Connective Tissue Growth Factor and Brain Natriuretic Peptide in Chronic Heart Failure Patients / 中国药师

ABSTRACT

Objective:To observe the effects of fluvastatin adjuvant therapy on plasma connective tissue growth factor ( CTGF) and brain natriuretic peptide (BNP) in chronic heart failure (CHF) patients.Methods:Totally 112 cases of chronic heart failure patients were randomly divided into two groups ,and 56 patients in the control group were treated with the conventional method , while 56 cases in the treatment group were given fluvastatin additionally .The course of treatment was 6 months.The clinical effect,and CTGF and BNP levels of the two groups were compared .Results: The efficiency rate of the treatment group was significantly higher than that of the control group with statistical significance (P0.05).After the treatment, the cardiac function indices (LVEF and FS) and lipid level (HDL-C) in the treat-ment group were increased obviously , which were higher than those in the control group; the cardiac function indices ( LVDD and LVSD) and lipid levels ( TC, TG and LDL-C) in the treatment group were decreased obviously , which were lower than those in the control group, and all the differences had statistical significance (P0.05).Conclusion: The conventional treatment combined with fluvastatin is effective in the patients with CHF, which can significantly reduce plasma BNP level and CTGF level .