The research progress of lncRNA as CeRNA in gastric cancer / 中国药理学通报

ABSTRACT

Recent studies have showed that RNAs regulate each other with microRNA ( miRNA ) response elements ( MREs ) , and this mechanism is known as “competing endogenous RNA (ceRNA)” hypothesis. Long noncoding RNAs(lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Ab-errant expression of lncRNAs has been found associated with gastric cancer, one of the most malignant tumors. Compelling evidence suggests that lncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several lncRNAs such as GAPLINC, BC032469, H19, HOTAIR, FER1L4 and MEG3 have been found to be associated with miRNAs in gastric cancer( GC) . It is tempting to speculate that a multitude of ln-cRNAs may interrupt definitive steps in GC suppressive and on-cogenic pathways. The uncovering of the underlying mechanisms of lncRNAs may benefit our understanding of gastric cancer′s pathogenesis.