Laminar shear stress result in maintaining the quiescence of MSCs / 局解手术学杂志
Journal of Regional Anatomy and Operative Surgery
; (6): 123-125,126, 2015.
Article
em Zh
| WPRIM
| ID: wpr-604864
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the effects of laminar shear stress ( LSS) on the proliferation and apoptosis of mesenchymal stem cells ( MSCs) . Methods The influences of laminar shear stress ( the physiological levels) on MSCs were studied. DNA synthesis and cell cycle were measured,to detect the cellular proliferation. The apoptosis-related gene expression ( Bcl-2/Bax) was examined to determine the effect of LSS. Results The percentage of MSCs’ proliferation rate was reduced by the fluid shear stress. Furthermore,it was detected that LSS exerted a potent suppression effect on MSC apoptosis. Conclusion These data revealed a critical role of LSS in maintaining the quies-cence of MSCs.
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WPRIM
Idioma:
Zh
Revista:
Journal of Regional Anatomy and Operative Surgery
Ano de publicação:
2015
Tipo de documento:
Article