Effect of Atorvastatin Calcium on the Carotid Intima-media Thickness and Related Indicators in Patients with Metabolic Syndrome / 中国药房
China Pharmacy
; (12): 2904-2905,2906, 2015.
Article
em Zh
| WPRIM
| ID: wpr-605080
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WPRO
ABSTRACT
OBJECTIVE:To investigate the effect of atorvastatin calcium on the carotid intima-media thickness(IMT)and other related indicators in patients with metabolic syndrome(MS). METHODS:The data of 1 444 patients with MS were retrospectively analyzed and randomly divided into observation group(874 cases)and control group(570 cases)by different medication. All patients were given healthy lifestyle,antihypertensive,hypoglycemia and lowering blood lipid guidance. On this basis,treatment group was orally given atorvastatin calcium 20 mg,once every evening. The follow-up was conducted for 3 years. The clinic data in 2 groups was compared,including body mass index(BMI),waist circumference(WC),systolic blood pressure(SBP),diastolic blood pressure (DBP),pulse pressure(PP),IMT,total cholesterol(TC),triglyceride(TG),low conspired lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),high-sensitivity C-reactive protein(hs-CRP),fasting plasma glucose(FPG)and incidence of adverse reactions before and after treatment. RESULTS:After treatment,compared with before and control group,the BMI、WC、SBP、DBP、PP、IMT、TC、TG、LDL-C、HDL-C、hs-CRP and FPG in observation group were significantly improved,only TG、LDL-C and HDL-C in control group were significantly improved,the differences were statistically significant(P<0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Based on the conventional treatment,atorvastatin calcium can effectively improve the IMT and blood lipid,blood pressure and blood glucose of patients with MS,with good safety.
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WPRIM
Tipo de estudo:
Guideline
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2015
Tipo de documento:
Article