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Clinical Observation of Candesartan Combined with Amlodipine Besylate in the Treatment of Elderly Hyper-tension / 中国药房
China Pharmacy ; (12): 2911-2912,2913, 2015.
Artigo em Chinês | WPRIM | ID: wpr-605088
ABSTRACT

OBJECTIVE:

To observe the clinical efficacy and safety of candesartan combined with amlodipine besylate in the treatment of elderly hypertension.

METHODS:

Totally 156 elderly patients with hypertension were randomly divided into control group and observation group. Patients in control group were orally given Amlodipine besylate tablets 5 mg in the morning,once a day. Patients in observation group were orally given Candesartan tablets 8 mg based on the treatment of control group,once a day. The course of both was 8 weeks. The clinical data was observed,including clinical efficacy,systolic blood pressure(SBP)and dia-stolic blood pressure(DBP)before and after treatment,fasting blood glucose(FPG),insulin resistance index(HOMA-IR),24 h urinary albumin total(mAlb),serum creatinine(SCr)and the incidence of adverse reactions.

RESULTS:

The total effective rate in observation group was significantly higher than control group;the HOMA-IR,mAlb and SCr in observation group were significant-ly lower than control group,with significant difference(P0.05). There were no obvious adverse reactions during treatment.

CONCLUSIONS:

Candesartan combined with amlodipine besylate has better efficacy than only amlodipine besylate in the treatment of elderly hypertension,with similar safety.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: China Pharmacy Ano de publicação: 2015 Tipo de documento: Artigo