Clinical Observation of Saxagliptin Combined with Metformin in the Treatment of Type 2 Diabetes / 中国药房
China Pharmacy
;
(12): 3761-3762,3763, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-605402
ABSTRACT
OBJECTIVE:
To observe the clinical efficacy and safety of saxagliptin combined with metformin in the treatment of type 2 diabetes.METHODS:
A total of 95 patients with type 2 diabetes were randomly divided into observation group(47 cases) and control group(48 cases). All of the patients received Metformin hydrochloride sustained-release tablets 0.5 g for continuous 4 weeks,orally,3 times a day;based on the treatment,control group was continuously given Metformin hydrochloride sustained-re-lease tablets 0.5 g for continuous 24 weeks,orally,3 times a day;observation group was given Saxagliptin tablets 5 mg continu-ous 24 weeks based on the treatment of control group,orally,once a day;the treatment course was 28 weeks. The clinic data was observed,including clinical efficacy,FPG,2 h PG,bed time glucose,HbA1c,BMI before and after treatment,incidence of hypoglyce-mia,severe hypoglycemia and adverse reactions.RESULTS:
The total effective rate in observation group was higher than control group,the incidence of hypoglycemia in observation group was lower than control group(P0.05).CONCLUSIONS:
Saxagliptin combined with metformin has better efficacy and safety than metformin alone in the treatment of type 2 diabetes,and can significantly reduce the incidence of hypoglycemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS