Determination of Content and Content Uniformity of Bisacodyl Enteric-coated Tablet by HPLC / 中国药房
China Pharmacy
;
(12): 2573-2574,2575, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-605729
ABSTRACT
OBJECTIVE:
To establish a method for the determination of content and content uniformity in Bisacodyl enter-ic-coated tablet.METHODS:
HPLC method was performed on the column of Agilent ZORBAX C18 with mobile phase of acetoni-trile-20 mmol/L ammonium acetate(adjusted pH to 5.0 with acetic acid)(55∶45,V/V),the detection wavelength was 265 nm,col-umn temperature was 30℃,flow rate was 1.0 ml/min,and the volume injection was 20 μl.RESULTS:
The linear range of bisaco-dyl was 50-1 000 μg/ml(r=0.999 9);RSDs of precision,stability and reproducibility tests were lower than 1%;recovery was 99.50%-101.17%(RSD=0.5%,n=9).CONCLUSIONS:
The method is reproducible with high accuracy,and suitable for the quali-ty control of Bisacodyl enteric-coated tablet.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2016
Tipo de documento:
Artigo
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