Research on relationship between serum complement C3 ,C4 and hepatitis grade level and liver fibrosis degree in patients with chronic hepatitis B / 中国免疫学杂志

ABSTRACT

Objective:To investigate the relationship between serum complement C 3,C4 and hepatitis grade level and liver fi-brosis degree in patients with chronic hepatitis B ( CHB ) .Methods: 185 cases of patients with CHB admitted in our hospital from March 2014 to 2016 March were collected as CHB group ,60 cases who were considered healthy at the same period as the control group.The serum complement C3,C4 of the two groups were detected and compared ,and relationship between serum complement C 3, C4 and hepatitis grade level and liver fibrosis degree was analyzed .Results:The serum C3,C4 levels in CHB group were significantly lower than the control group (t=10.476,9.172,P<0.05).The differences of serum C3,C4 levels among different levels of hepatitis activity were significant ( F=4.321 ,3.495 ,P<0.05 ) ,and differences among different levels of hepatic fibrosis grading were significant (F=3.861,4.541,P<0.05).The serum C3,C4 levels were negatively associated with G rating of hepatitis activity (r=-0.575,-0.542,P<0.05),and were negatively associated with S rating (≥S1) of liver fibrosis (r=-0.512,-0.636,P<0.05).Conclusion:The serum complement C3,C4 levels is closely related with hepatitis grade level and liver fibrosis degree in patients with CHB ,it can be used as secondary predictors of hepatic pathological status in CHB patients .