Clinical significance of serum anti-CCP antibody and TNF-α expression in patients with rheumatoid arthritis / 重庆医学

ABSTRACT

Objective To investigate the value of serum anti-CCP antibody and TNF-α in the diagnosis and therapeutic effect evaluation of rheumatoid arthritis(RA).Methods One hundred and sixty-eight RA patients in our hospital from January 2012 to December 2015 were selected and included 86 cases of active stage(active group)and 80 cases of remission stage(remission group).Other 80 outpatient healthy controls served as the control group.The levels of RF,anti-CCP antibody and TNF-α in the active group,remission group and control group were measured by using the immunoadsorption and ELISA.Then the detection results were analyzed.Results The serum anti-CCP antibody and TNF-α levels in the active group and remission group were higher than those in the control group,moreover the serum anti-CCP antibody and TNF-α levels in the active group were significantly higher than those in the remission group,the difference was statistically significant(P＜0.05).Comparing the RA patients with the control group,the sensitivity and specificity of combined detection of anti-CCP antibody and TNF-α was 73.8％ and 97.5％,which were higher than those of other 2-index combined detection,the difference was statistically significant(P＜0.05).The serum TNF-α level was positively correlated with the DAS28 score(P＜0.01).Conclusion The combined detection of serum anti-CCP antibody and TNF-α has an important clinical value for the RA diagnosis and disease condition monitoring.