Development of high-performance liquid chromatography methods for the anticoccidials: toltrazuril and diclazuril
Korean Journal of Veterinary Research
; : 223-226, 2017.
Article
em Ko
| WPRIM
| ID: wpr-60681
Biblioteca responsável:
WPRO
ABSTRACT
This study was undertaken to develop new analytical methods for assessment of anticoccidials. High-performance liquid chromatography (HPLC) was found to be a fast, reliable, and practical method. The anticoccidials used in this experiment were toltrazuril and diclazuril, and the analysis factors were specificity, linearity, accuracy, repeatability, and intermediate precision. The linearity of each anticoccidial was better than 0.99, and the accuracies were 99.5% and 99.1% with relative SD of 0.5 and 0.4, respectively. To assess whether the developed HPLC method could be effectively applied, toltrazuril and diclazuril post-market veterinary products (five products) that are currently sold were tested. The results revealed no non-compliant items and the method was applied successfully. Therefore, the newly developed HPLC method for anticoccidial assessment described in this study may be useful as a reference method in the Korean Standards of Veterinary Pharmaceuticals for the analysis of toltrazuril and diclazuril.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Cromatografia Líquida de Alta Pressão
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Cromatografia Líquida
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Sensibilidade e Especificidade
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Coccidiostáticos
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Drogas Veterinárias
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Métodos
Tipo de estudo:
Diagnostic_studies
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Guideline
Idioma:
Ko
Revista:
Korean Journal of Veterinary Research
Ano de publicação:
2017
Tipo de documento:
Article