Comparison of Therapeutic Efficacy of Lobaplatin or Cisplatin Combined with Tegafur, Gimeracil and Oteracil Potassium in the Treatment of Advanced Metastatic Breast Cancer / 中国药房
China Pharmacy
;
(12): 3377-3379, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-607091
ABSTRACT
OBJECTIVE:
To compare therapeutic efficacy and safety of lobaplatin or cisplatin combined with tegafur,gimeracil and oteracil potassium in the treatment of advanced metastatic breast cancer.METHODS:
A total of 160 patients with advanced metastatic breast cancer were randomly divided into observation group and control group,with 80 cases in each group.Control group was given Cisplatin injection 30 mg/m2 intravenously,every 3 weeks Tegafur,Gimeracil and Oteracil Potassium capsules 50 mg orally after meal,twice a day,for consecutive 14 days.Observation group was given Lobaplatin for injection 30 mg/m2 intravenously,every 3 weeks+Tegafur,Gimeracil and Oteracil Potassium capsules (same usage and dosage as control group),every 3 weeks.A treatment course lasted for 3 weeks,and both groups received 2 courses.Short-term efficacies (ORR、DCR),chemotherapy effects of lymph node,lung,bone and liver,ADR and long-term efficacy were compared between 2 groups.RESULTS:
After treatment,ORR(67.50% vs.46.25%),DCR(85.00% vs.66.25%),ORR of lymph node metastasis (71.43% vs.47.83%),ORR of lung metastasis (60.71% vs.40.00%),DCR of lung metastasis (78.57% vs.56.00%),ORR of bone metastasis (28.57% vs.16.67%),1-year survival rates (75.00% vs.52.50%) and 2-years survival rates (42.50% vs.17.50%) of observation group were significantly higher than control group;the incidence of chemotherapy ADR in observation group was significantly lower than control group (43.75% vs.70.00%),with statistical significance (P<0.05).There was no statistical significance in lymph node metastasis DCR,bone tissue metastasis DCR,liver metastasis ORR and DCR,or half year sarvival rate between 2 groups (P>0.05).CONCLUSIONS:
Compared to cisplatin combined with tegafur,gimeracil and oteracil potassium,lobaplatin combined with tegafur,gimeracil and oteracil potassium show better short-term therapeutic efficacy,therapeutic efficacy of lymph node metastasis,bone metastasis and lung metastasis,more than 1-year long-term therapeutic efficacy and safety in the treatment of advanced metastatic breast cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS