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Relevance analysis on HLA-DRB1 alleles andocculthepatits B virus infection / 中国输血杂志
Chinese Journal of Blood Transfusion ; (12): 670-673, 2017.
Artigo em Chinês | WPRIM | ID: wpr-607386
ABSTRACT
Objective To study the HLA-DRB1 genotupe and their relation with OBI infection.Methods HLA-DRB1 genotyping was conducted in 102 patients OBI infection and 201 health controls,by using polymerase chain reaction sequence-based typing (PCR-SBT)method.The association between HLA-DRB1 genotype and OBI was also studied.Results Compared to 201 health controls,the allele frequency of HLA-DRB1 * 0405 (1.980 4%) (x2 =12.477 0,P =0.000 0,OR =16.367 3) * 0803 (4.257 3%) (x2 =30.689 8,P =0.000 0,OR =36.454 5)、* 1101 (5.545 9%) (x2 =4.471 2,P =0.034 5,OR =1.903 8)、* 1201 (1.481 6%) (x2 =8.591 9,P =0.003 4,OR =12.151 5) were markedly higher.The allele frequency of HLA-DRB1 * 0701(2.230 8%) (x2 =5.585 5,P=0.018 1,OR=0.417 7)、* 1301 (0.245 4%) (x2 =4.513 7,P=0.033 6,OR=0.147 4) 、* 1302(0.491 4%) (x2=11.369 1,P=0.000 7,OR=0.000 0) 、* 1312(0.245 4%) (x2 =5.0198,P=0.025 1,OR=0.136 5) 、* 1501(4.257 3%) (x2=10.763 1,P=0.001 0,OR=0.000 0)was obviously lower than than in HBV patients.Conclusion HLA-DRB1 * 0701、* 1301、* 1302、* 1312、* 1501 are closely related with susceptibility to OBI,and HLA-DRB1 * 0405、* 0803、* 1101、* 1201 is closely related with resistance to OBI.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Blood Transfusion Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Blood Transfusion Ano de publicação: 2017 Tipo de documento: Artigo