Therapeutic Implications of a Barrier-based Pathogenesis of Atopic Dermatitis
Annals of Dermatology
;
: 245-254, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-60741
ABSTRACT
In this review, I first provide relevant background information about normal epidermal barrier structure and function. I then update recent information about how inherited defects in either filaggrin and/or in the serine protease inhibitor, lymphoepithelial Kazal-type inhibitor 1, converge to stimulate the development of atopic dermatitis (AD). Next I explain the multiple mechanisms whereby a primary barrier abnormality in AD can lead to inflammation. Furthermore, I explore how certain acquired stressors, such as a reduced external humidity, high pH soaps/surfactants, psychological stress, as well as secondary Staphylococcus aureus infections initiate or further aggravate AD. Finally, and most importantly, I compare various therapeutic paradigms for AD, highlighting the risks and benefits of glucocorticoids and immunomodulators vs. corrective, lipid replacement therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Staphylococcus aureus
/
Estresse Psicológico
/
Medição de Risco
/
Dermatite Atópica
/
Serina Proteases
/
Glucocorticoides
/
Umidade
/
Concentração de Íons de Hidrogênio
/
Fatores Imunológicos
/
Inflamação
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2010
Tipo de documento:
Artigo
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