Association of Toll-Like Receptor Gene with Crohn's Disease in Koreans / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 377-383, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-60800
ABSTRACT
BACKGROUND/AIMS:
Toll-like receptors (TLRs) serve as pattern recognition receptors that recognize specific molecular patterns of pathogens and can mediate the production of proinflammatory cytokines. Recently, TLRs have been identified as susceptibility genes for Crohn's disease (CD) in several studies from Western populations. We investigated the association of genetic variations in TLR4 and TLR9 with CD in Korean population.METHODS:
In 380 CD cases and 380 healthy controls, we performed genotyping for TLR4 Asp299Gly (rs4986790) and Thr399Ile (rs4986791). The genetic variations in the TLR9 -1237T/C (rs5743836) were also examined.RESULTS:
Among CD patients genotyped for TLR4 Asp299Gly and TLR9 -1237T/C, none had variant alleles. Similarly, none of the subjects genotyped for TLR4 Thr399Ile showed genetic variations.CONCLUSIONS:
Our results indicate that the major genetic variations in TLR4 and TLR9 are rare and may not be associated with susceptibility to CD in Koreans.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Crohn
/
Predisposição Genética para Doença
/
Povo Asiático
/
Alelos
/
Receptor Toll-Like 9
/
Receptor 4 Toll-Like
/
República da Coreia
/
Genótipo
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2009
Tipo de documento:
Artigo
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