The expression and prognostic significance of Fibulin-5 in gastric carcinoma / 中华普通外科杂志
Chinese Journal of General Surgery
;
(12): 247-250, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-608243
ABSTRACT
Objective To study the expression of Fibulin-5 in gastric cancer and its correlation with the prognosis of gastric cancer.Methods Tissue chips from 90 gastric cancer cases were used to study the expression of Fibulin-5 protein in cancer tissue and para-carcinoma tissue by immunohistochemistry,and analyze the correlation of Fibulin-5 expression and clinical pathological characteristics.Results The expression of Fibulin-5 in gastric cancer tissue was higher than that of para-carcinoma tissue [cytoplasm(6.2±4.2) vs.(5.1 ±3.7);nucleus(7.2 ±3.8) vs.(4.9 ±2.5),all P<0.05],which was positively related with patient's age (r =0.213,P =0.044) in the cytoplasm of cancerous tissue.The expression of Fibulin-5 in the cytoplasm of cancerous tissue was negatively related with patient's overall survival (25% vs.56%,P =0.027),which was an independent predictor (P =0.037).Conclusion Fibulin-5 is an independent prognostic factor of gastric cancer,its expression might be related with shortend patient's survival time.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of General Surgery
Ano de publicação:
2017
Tipo de documento:
Artigo
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