Clinical Effects and Safety of Delapril in Patients with Essential Hypertension
Korean Circulation Journal
;
: 676-682, 1992.
Artigo
em Coreano
| WPRIM
| ID: wpr-60836
ABSTRACT
BACKGROUND:
To evaluate depressure effect and safety of delapril, a new ACE inhibitor, in Korea.METHOD:
Thirty three patients, aged 37-69, with mild to moderate essential hypertension were first observed for 2 weeks with placebo followed by administration of 15mg of delapril twice daily for 2 weeks, then doubled dosage to 30mg b.i.d. and combined with 25mg of dihydrochlorothiazide if optimal BP were not obtained at the end of 4th week, continued the same dose until the end of 10 week's trial period.RESULT:
BP dropped 15/9mmHg inaverage at the end of 10th week rewarding 70% of cumulative effectiveness. Most frequent side reaction was dry cough, occurred in 9% of patients followed by chest tightness, headache, constipation and transient elevation of GPT.CONCLUSION:
Delapril 15-30mg twice daily as monotheraphy or combined with diuretics is well tolerated and effective in the treatment of mild to moderate essential hypertension.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recompensa
/
Tórax
/
Constipação Intestinal
/
Tosse
/
Diuréticos
/
Cefaleia
/
Hidroclorotiazida
/
Hipertensão
/
Coreia (Geográfico)
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Circulation Journal
Ano de publicação:
1992
Tipo de documento:
Artigo
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