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Prothrombin complex concentrate carrying anionic lipid-coated microbubbles enhanced therapeutic ultrasound in hemostatic treatment for renal trauma in rabbits models / 中国医学影像技术
Chinese Journal of Medical Imaging Technology ; (12): 494-498, 2017.
Artigo em Chinês | WPRIM | ID: wpr-608669
ABSTRACT
Objective To investigate the hemostatic effects of prothrombin complex concentrate carrying anionic lipid coated microbubbles (PCCMB) enhanced therapeutic ultrasound for renal trauma in rabbits models.Methods Twenty-four healthy New Zealand rabbits were randomly divided into three groups (each n=8),including simple therapeutic ultrasound group (US group),simple PCCMB injection group (SHAM group) and PCCMB injection combined with therapeutic ultrasound group (PCCMB+US group).Visual bleeding score and 10-min bleeding volume were evaluated for hemostatic efficacy.CEUS was used to assess the kidney perfusion in SHAM and PCCMB+US groups before therapeutic ultrasound,immediately and 60 min after therapeutic ultrasound.And CEUS was performed on US group 60 min after therapeutic ultrasound.The acoustic peak intensity (PI) of kidney in rabbit was measured.Results The treatment was successfully completed in all the experimental rabbits.The bleeding scores and the 10-min hemorrhagic volumes decreased significantly in PCCMB+US group compared with the other two groups (both P<0.05).After therapeutic ultrasound,visual bleeding score of PCCMB+US group was respectively lower than that of US group and SHAM group (both P< 0.05).In PCCMB+ US group,PI obtained immediately and 60 min after therapeutic ultrasound were higher than that obtained before therapeutic ultrasound (both P<0.05).There was no significant difference of PI before and after therapeutic ultrasound in US and SHAM groups (all P>0.05).Conclusion PCCMB enhanced therapeutic ultrasound provides an effective way for renal trauma in rabbits.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of Medical Imaging Technology Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of Medical Imaging Technology Ano de publicação: 2017 Tipo de documento: Artigo