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Clinical significance of the expression of D-amino acid oxidase gene in hepatocellular carcinoma tissues / 国际检验医学杂志
International Journal of Laboratory Medicine ; (12): 2068-2070, 2017.
Artigo em Chinês | WPRIM | ID: wpr-608793
ABSTRACT
Objective To study the clinical significance of the expression of D-amino acid oxidase(DAO) in hepatocellular carcinoma(HCC) tissues.Methods The gene expression profiles and related clinical data of 214 HCC cases were collected.Univariate and multivariate analyses were conducted to investigate the association between DAO expression levels,clinical traits,the prognosis.Results Univariate analysis indicated that there were a lower level of blood alpha fetoprotein(AFP,P=0.001),a smaller number of nodules(P=0.042),a better TNM stage(P=0.014),a lower metastasis risk(P=0.001) and a better prognosis(P=0.011)in the samples with high DAO expression.Multivariate analysis also indicated a lower AFP level(OR0.162,95%CI0.078-0.336) and metastasis risk(OR0.140,95%CI0.069-0.284) in the samples with high DAO expression,as well as a better prognosis(OR0.833,95%CI0.700-0.992).Conclusion DAO expression was associated with blood AFP levels,metastasis risk and prognosis in HCC,and its high expression was a protective factor for HCC.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: International Journal of Laboratory Medicine Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: International Journal of Laboratory Medicine Ano de publicação: 2017 Tipo de documento: Artigo