Different expression patterns of β-catenin and its correlation with clinicopathological facters in colorectal cancer / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
;
(12): 596-600,605, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-609139
ABSTRACT
To observe different expression patterns of β-catenin and its clinical significance in colorectal cancer (CRC).Methods A total of 181 cases of CRC tissues and 30 cases of normal colorectal tissue were investigated by immunohistochemistry for the expression of β-catenin.Results The expression rate of β-catenin was 56.9% (103/181) in CRC,and higher than that in normal colorectal tissue (P < 0.05).The overexpression of nuclear β-catenin was significantly correlated with histological differentiation,lymph node metastasis and Dukes' stage in CRC (P < 0.05),and no relationship with other pathological parameters,such as age,gender and the depth of infiltration.The incomplete membranous expression of β-catenin was significantly correlated with histological differentiation,the depth of infiltration,lymph node metastasis and Dukes' stage in CRC (P < 0.05).The high expression of nuclear β-catenin related to histological differentiation and Dukes' stage in CRC (P < 0.05).In the follow-up data of 82 cases of CRC,the expression of nuclear β-catenin was associated with poor prognosis,and the 5-year survival rate was significantly lower than that of self-control groups (P < 0.05).Conclusion β-catenin plays important roles in colorectal carcinogenesis.Abnormal expression of β-catenin was related to the aggressive progression of CRC and may be helpful for evaluating the prognosis of patients with CRC.β-catenin is expected to become a new target for diagnosis and treatment of CRC in future.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical and Experimental Pathology
Ano de publicação:
2017
Tipo de documento:
Artigo
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