"The modulating effect of 5-HT1B and D1DR receptors in neurons within ""SNr/GPi-VL-SMA"" pathway on exercise induced fatigue" / 中国康复医学杂志
Chinese Journal of Rehabilitation Medicine
;
(12): 501-508, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-609691
ABSTRACT
Objective:
To observe the changes of 5-HT1B and D1DR expression in nucleus of SNr/GPi-VL-SMA pathway in pre and post-exhaustive exercise,and investigate the central mechanism of SNr/GPi-VL-SMA pathway modulating the occurrence and development of exercise-induced fatigue.Method:
Twenty-four male Wistar rats were randomly divided into control group (CG),immediately after exhaustion group (EG),and 90min after recovery group (RG),each consists of 8 rats.The expression level of 5-HT1B and D1DR receptors in each group were observed with the immunohistochemistry technique.Result:
Compared with CG,the positive cell area/scanning area value (R value) and the average optical density value (AOD value) of 5-HT1B receptor in SNr and GPi of the EG and RG rats both decreased significantly (P < 0.05),while the R value and AOD value of D1DR both increased significantly(P< 0.05).The R value and AOD value of 5-HT1B receptor in VL of EG and RG rats increased significantly(P<0.05,P<0.01).In SMA,the R value and AOD value of 5-HT1B receptor of EG and RG rats increased significantly (P< 0.05),while,the R value and AOD value of D1DR receptor decreased significantly (P < 0.05).Conclusion:
Changes of 5-HT1B receptor and D1DR receptor expression in the nuclei of ‘SNr/GPi-VL-SMA'pathway caused the changes of the neurotransmitters release,thus affecting the excitability of the electrical activity of neurons,this might be one of the important ways for ‘SNr/GPi-VL-SMA'pathway modulating the exercise-induced fatigue and exercise performance.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Rehabilitation Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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