Preparation and Characterization of Aspirin Phospholipid Complex / 中国药房
China Pharmacy
;
(12): 3562-3565, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-611005
ABSTRACT
OBJECTIVE:
To prepare aspirin phospholipid complex (ASP-PC) and conduct the characterization.METHODS:
Using the combination rate of ASP and PC as index,single factor test was used to screen the preparation method of ASP-PC,PC type,solvent type,reaction time,reaction temperature,solvent volume and drug-lipid ratio. The verification test was conducted. UV spectrophotometry,Thermogravimetric analysis,X-ray diffraction and Fourier transform infrared spectroscopy were used for the characterization of ASP-PC.RESULTS:
Magnetic stirring-condensing reflux method was adopted,drug-soybean phospholipids ratio was 13 (mol/mol),solvent was tetrahydrofuran,reacting for 3 h under 58 ℃. The average combination rate of prepared ASP-PC was 83.52%(RSD=1.16%,n=3). Compared with ASP,physical mixture of ASP and PC,UV spectrum showed that ASP-PC had no new absorption peak. Thermogravimetric analysis,X-ray diffraction and Fourier transform infrared spectroscopy showed the ASP and PC in ASP-PC were interacted;and ASP-PC changed little in quality within 0-300 ℃.CONCLUSIONS:
ASP-PC can be successfully prepared,in which,ASP and PC were combined successfully;while there are still trace amounts of ASP in the form of crystals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2017
Tipo de documento:
Artigo
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