Clinical effect and safety of low dose aspirin in preventing lower extremity venous thrombosis after cesarean section / 中国生化药物杂志

ABSTRACT

Objective To investigate the clinical efficacy and safety of low-dose aspirin in prevention of lower extremity deep venous thrombosis after cesarean section. Methods from January 2016 to March 2017 in our hospital obstetrics and Gynecology cesarean section in 374 cases as the research object, using the method of random number table according to the proportion of 11 were divided into control group and observation group, each group of the 187 cases, the control group after cesarean section treated with routine comprehensive preventive measures, the observation group in the control group received the low-dose aspirin treatment. Observation group 2 postpartum in January the incidence of deep venous thrombosis, postoperative 12 h, postoperative serum 7 d two D- dimer (D-D), fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT) and platelet count (PLT) and blood rheology index, statistics of the 2 groups the incidence of bleeding complications. Results Deep venous thrombosis in the observation group was significantly lower than the control group (P<0.05); the 2 group after 5D-D and FIB and 12 h after operation were significantly decreased (P<0.05), and the observation group and the control group in the same period were significantly decreased (P<0.05); 2 groups were PT, APTT, PLT showed no significant difference compared with the preoperative, and the observation group and the control group in the same period. There was no statistically significant difference ; 2 group 7 d after operation and high blood viscosity, whole blood viscosity, whole blood low shear viscosity, plasma viscosity and postoperative 12 h compared were significantly decreased (P<0.05), and the observation group with the same period compared with the control group decreased significantly (P<0.05); postoperative 7 d erythrocyte deformation index and postoperative 12 h were significantly increased (P<0.05), and the observation group and the control group in the same period compared significantly increased (P<0.05); the incidence of bleeding complications was not statistically significant 2 after the operation of group. Conclusion Hypercoagulability of low-dose aspirin helps improve puerpera after cesarean section, reduce blood viscosity, reduce the incidence of venous thrombosis, does not increase the incidence of bleeding, clinical application of good safety, which is worthy of clinical application.