Study on the effects of calcium dobesilate on serum Hs-CRP and TNF-α and other micro-inflammatory in patients with maintenance hemodialysis / 中国生化药物杂志

ABSTRACT

Objective To study the effect of calcium dobesilate on serum Hs-CRP and TNF-α and other micro-inflammatory in patients with maintenance hemodialysis. Methods 74 patients with chronic renal failure undergoing maintenance hemodialysis from April 2015 to December 2016, were randomly divided into the control group(n=39) and the observation group(n=35). All patients are in line with the diagnostic criteria of the guidelines for the diagnosis and treatment of chronic renal failure, established by the Chinese Academy of traditional Chinese Medicine. All patients in the two groups were given atorvastatin, at this basis, the observation group was given calcium dobesilate. After treatment, hypersensitive inflammatory markers, such as C-reactive protein (hs-CRP), tumor necrosis factor -α (TNF-α), as well as nutrient index plasma albumin (ALB) and the pre-albumin (PA) level in the two groups were compared. Results The hs-CRP, TNF-α in the observation groupwere lower than that in the control group, the differences was statistically significant (P<0.05). The ALB, PA in the observation group was significantly higher than that in the control group, the differences was statistically significant (P<0.05). Conclusion Atorvastatin combined with calcium dobesilate was used in the patients with maintenance hemodialysis which can improve thenutritional status and inflammatory conditions, it is safety and is worth popularizing,.